The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxyge… (2025)

Anti-Inflammatory Potential of Quercetin: From Chemistry and Mechanistic Insight to Nanoformulations

Diwakar Aggarwal, Mayank Chaudhary, Sachin Kumar Mandotra, Hardeep Singh Tuli, Ritu Chauhan, Naveen Chandra Joshi, Damandeep Kaur, Laurent Dufossé, Abhishek Chauhan

2025, Current Research in Pharmacology and Drug Discovery, с.100217

Plant molecules reinforce bone repair: Novel insights into phenol-modified bone tissue engineering scaffolds for the treatment of bone defects

Yuhang Chen, Weikang Gan, Zhangrong Cheng, Anran Zhang, Pengzhi Shi, Yukun Zhang

2024, Materials Today Bio, с.100920

Kaempferol: Paving the path for advanced treatments in aging-related diseases

Md Sadique Hussain, Abdulmalik Saleh Alfawaz Altamimi, Muhammad Afzal, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Gaurav Gupta, Moyad Shahwan, Neelima Kukreti, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan

2024, Experimental Gerontology, с.112389

Raspberry ameliorates renal fibrosis in rats with chronic kidney disease via the PI3K/Akt pathway

Jingjing Hu, Xingyuan Pang, Xiao Liang, Xinyuan Shao, Qijun Xia, Jianwen Sun, Yuxiao Wang, Guichun Wang, Shuhan Li, Liangping Zha, Jian Guo, Chengjun Peng, Peng Huang, Yang Ding, Cheng Jin, Ning He, Yuzhe Huang, Shuangying Gui

2025, Phytomedicine, с.156589

Quercetin tetraacetyl derivative inhibits LPS-induced nitric oxide synthase (iNOS) expression in J774A.1 cells

M.G. Ortega, A.C. Saragusti, J.L. Cabrera, G.A. Chiabrando

2010, Archives of Biochemistry and Biophysics, №2, с.105-110

Focus on the high therapeutic potentials of quercetin and its derivatives

Axelle Septembre-Malaterre, Ahcène Boumendjel, Anne-Laure Sandenon Seteyen, Chailas Boina, Philippe Gasque, Pascale Guiraud, Jimmy Sélambarom

2022, Phytomedicine Plus, №1, с.100220

Application of Quercetin and its Novel Formulations in the Treatment of Malignancies of Central Nervous System: An Updated Review of Current Evidence based on Molecular Mechanisms

Mohammad Saleh Jamshidi-Mouselou, Amirhossein Hashemi, Mohammad Sobhan Jamshidi-Mouselou, Tahereh Farkhondeh, Mohammad Hossein Pourhanifeh, Saeed Samarghandian

<jats:sec> Abstract: Quercetin, a naturally occurring polyphenolic compound found in abundance in vegetables and fruits, has emerged as a compelling subject of study in cancer treatment. This comprehensive review delves into the significance and originality of quercetin's multifaceted mechanisms of action, with a particular focus on its application in various brain tumors such as glioblastoma, glioma, neuroblastoma, astrocytoma, and medulloblastoma. This review scrutinizes the distinctive facets of quercetin's anti-cancer properties, highlighting its capacity to modulate intricate signaling pathways, trigger apoptosis, impede cell migration, and enhance radiosensitivity in brain tumor cells. Significantly, it synthesizes recent research findings, providing insights into potential structure-activity relationships that hold promise for developing novel quercetin derivatives with heightened effectiveness. By unraveling the unique attributes of quercetin's anti-brain tumor effects and exploring its untapped potential in combination therapies, this review contributes to a deeper comprehension of quercetin's role as a prospective candidate for advancing innovative treatments for brain cancer. </jats:sec>

2024, Current Medicinal Chemistry, №26, с.4180-4198

Network pharmacology and in vitro testing of Theobroma cacao extract’s antioxidative activity and its effects on cancer cell survival

Priyanka P. Patil, Vishal S. Patil, Pukar Khanal, Harish R. Darasaguppe, Rajitha Charla, Arati Bhatkande, Basanagouda M. Patil, Subarna Roy

Theobroma cacao L. is a commercially important food/beverage and is used as traditional medicine worldwide against a variety of ailments. In the present study, computational biology approaches were implemented to elucidate the possible role of cocoa in cancer therapy. Bioactives of cocoa were retrieved from the PubChem database and queried for targets involved in cancer pathogenesis using BindingDB (similarity index ≥0.7). Later, the protein-protein interactions network was investigated using STRING and compound-protein via Cytoscape. In addition, intermolecular interactions were investigated via molecular docking. Also, the stability of the representative complex Hirsutrin-epidermal growth factor receptor (EGFR) complex was explored using molecular dynamics simulations. Crude extract metabolite profile was carried out by LC-MS. Further, anti-oxidant and cytotoxicity studies were performed in Chinese hamster ovary (normal) and Ehrlich ascites carcinoma (cancer) cell lines. Herein, the gene set enrichment and network analysis revealed 34 bioactives in cocoa targeting 50 proteins regulating 21 pathways involved in cancer and oxidative stress in humans. EGFR scored the highest edge count amongst 50 targets modulating 21 key pathways. Hence, it was selected as a promising anticancer target in this study. Structural refinement of EGFR was performed via all-atom molecular dynamics simulations in explicit solvent. A complex EGFR-Hirsutrin showed the least binding energy (-7.2 kcal/mol) and conserved non-bonded contacts with binding pocket residues. A stable complex formation of EGFR-Hirsutrin was observed during 100 ns MD simulation. In vitro studies corroborated antioxidant activity for cocoa extract and showed a significantly higher cytotoxic effect on cancer cells compared to normal cells. Our study virtually predicts anti-cancer activity for cocoa affected by hirsutrin inhibiting EGFR. Further wet-lab studies are needed to establish cocoa extract against cancer and oxidative stress.

2022, PLOS ONE, №4, с.e0259757

Scutellaria brevibracteata Stapf and active principles with anti-inflammatory effects through regulation of NF-κB/COX-2/iNOS pathways

Zeynep Dogan, Gokcen Telli, Banu Cahide Tel, Iclal Saracoglu

2022, Fitoterapia, с.105159

Anticancer activities of cranberry phytochemicals: An update

Catherine C. Neto, Jon W. Amoroso, Anne M. Liberty

2008, Molecular Nutrition & Food Research